PDGF Is Having a Moment.
Here's What Actually Matters.
Growth factors are all over your feed right now — and like most things that go viral in the aesthetics world, the full picture is more interesting than the hot take. Here's what PDGF actually is, why we believe in it, how we use it, and why the science behind it is genuinely impressive.
Let's start with the molecule itself.
Platelet-derived growth factor — PDGF — isn't new, and it isn't a trend. It was discovered in the 1970s, FDA-approved for medical use in the 1990s, and has been used in over five million patients across wound healing, orthopedics, and dental surgery. It's one of the most studied growth factors in medicine, with a safety record built over decades of clinical use.
What is new is its arrival in aesthetic medicine — and that's where things get interesting, nuanced, and occasionally noisy on social media. We'll come back to the noise. First, let's talk about what PDGF actually does, because the biology is genuinely impressive.
When your skin is stimulated or injured, your body releases PDGF as part of the repair cascade. It binds to receptors on fibroblast cells — the cells responsible for producing collagen and elastin — and tells them to activate, multiply, and rebuild. It also promotes angiogenesis, the formation of new blood vessels that bring oxygen and nutrients to healing tissue. In other words, PDGF is your skin's own instruction manual for regeneration. Ariessence Pure PDGF+ is a laboratory-engineered version of that signal — pharmaceutical-grade, sterile, and precisely concentrated to deliver that same message at a potency your body couldn't generate on its own.
What makes Ariessence different from everything else.
PRP has been the gold standard in growth factor aesthetics for years — draw your blood, spin it, apply it. It works, and we respect it. But PRP has a fundamental variability problem: your results depend on your platelet count that day, your overall health, and the quality of processing. Every session is a slightly different product.
Ariessence Pure PDGF+ solves that problem completely. It contains a single, precisely dosed, recombinant growth factor — SH-Polypeptide-59 dimer — produced under pharmaceutical manufacturing standards. Same concentration. Same potency. Same result, every time. No blood draw, no centrifuge, no waiting. And because it's synthetically produced, it contains no human or animal DNA or mRNA — making it one of the cleanest regenerative products on the market.
Four ingredients. Nothing else.
No fillers. No additives. No human or animal biological material of any kind.
How we use it at New Age Medspa.
Context matters enormously with PDGF+. Like most powerful tools in aesthetics, its effectiveness depends entirely on how and when it's applied. Here's our approach — and why each application makes clinical sense.
"The delivery method matters as much as the molecule. PDGF+ in the right hands, at the right time, in the right application — that's when you see results that actually change how your skin behaves."
The science caught up in 2025 — and it's worth knowing about.
One of the most common critiques of newer aesthetic treatments is that the enthusiasm outruns the evidence. With PDGF+ applied topically post-procedure, that's no longer a fair criticism. In 2025, researchers published the first prospective, randomized, controlled clinical trial specifically examining pure PDGF after RF microneedling — the highest standard of clinical evidence.
Pure PDGF was applied topically following RF microneedling and compared against the current standard of care. At both 7 and 30 days, PDGF outperformed the control group on clinician global aesthetic improvement scales. Objective image analysis showed improvement in 6 of 7 measured outcomes. Patient-reported satisfaction scores were higher across the board. And critically — no serious adverse effects were reported.
This is the kind of data that matters. Not anecdotes. Not before-and-afters on Instagram. A blinded, prospective, randomized, controlled trial — the same standard we use to evaluate pharmaceutical drugs. The results were clear: PDGF+ amplifies microneedling outcomes, accelerates healing, and does so safely.
We were already confident in the treatment before this study. Now there's a peer-reviewed clinical trial to point to as well.
A word on the noise.
If you've seen chatter about PDGF online recently — some positive, some concerned — that's actually a sign that the aesthetic community is doing its job. Growth factors are being taken seriously, debated seriously, and studied seriously. That's a good thing.
What we'd encourage is the same thing we encourage about every treatment: ask your provider specific questions. What product are you using? How is it being applied? What does the evidence say about that specific application? The answers matter. The delivery method, the formulation, and the clinical context all determine the outcome. Not every use of PDGF is the same — and the difference between applications is exactly the kind of thing a good consultation is designed to address.
At New Age Medspa, we're happy to talk through all of it. That's the conversation we like having.
Decades of safety. A 2025 clinical trial. Four clean ingredients. Real results.
PDGF isn't a trend we adopted because it went viral. It's a growth factor with one of the longest safety records in medicine, now backed by randomized controlled evidence for exactly how we use it. The molecule is exceptional. The formulation is pharmaceutical-grade. And the results — particularly when paired with microneedling — are some of the most consistent we've seen in regenerative aesthetics. That's why it's on our menu, and that's why it's staying there.
Ready to see what
PDGF+ can do for your skin?
Book a consultation and we'll build a treatment plan around your skin, your goals, and the science that supports getting you there.
